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Neurological Disorders
(Scientific citations linking vaccines and neurological disorders)

      This site documents scientific links between vaccines and neurological disorders, including: alterations to the nervous system, autism, demyelination, seizures, convulsions, epilepsy, brain swelling, and other neurological complications.


400 Critical Vaccine Studies

Vaccines and Nervous System Changes:

  • Bondarev, VN et al, "The Changes of the Nervous System in Children After Vaccination", Pediatria, Jun 1969; 48:20-24.
  • Ehrengut W, "Central nervous sequelae of vaccinations," Lancet 1986 May 31;1(8492):1275-1276.
  • Provvidenza, G et al, [On a Case of Benign Acute Cerebellar Ataxia in Childhood], Arch Ital Sci Med Trop, 43:189-194, Apr 1962.
  • Katsilambros, L, "[The Phenomenom of Apathy in Man and Animals After the Injection of Viruses in Very High Doses. Clinical Data]", Rev Med Moyen Orient, 20:539-546, Nov - Dec 1963.

 Vaccines and Autism:

  • Eggers, C, "Autistic Syndrome (Kanner) And Vaccinations against Smallpox", Klin Paediatr, Mar 1976, 188(2):172-180.
  • Kiln MR, "Autism, inflammatory bowel disease, and MMR vaccine." Lancet 1998 May 2;351(9112):1358.
  •  Selway, "MMR vaccination and autism 1998. Medical practitioners need to give more than reassurance." BMJ 1998 Jun 13;316(7147):1824.
  •  Nicoll A, Elliman D, Ross E, "MMR vaccination and autism 1998," MJ 1998 Mar 7;316(7133):715-716.
  •  Lindley K J, Milla PJ, "Autism, inflammatory bowel disease, and MMR vaccine."Lancet 1998 Mar 21;351(9106):907-908.
  • Bedford H, et al, "Autism, inflammatory bowel disease, and MMR vaccine." Lancet 1998 Mar 21;351(9106):907.
  • Vijendra K. Singh, Sheren X. Lin, and Victor C. Yang, "Serological Association of Measles Virus and Human Herpesvirus-6 with Brain Autoantibodies in Autism," Clinical Immunology and Immunopathology, Oct 1998, Vol. 89, No. 1, p 105-108. ["None of the autistic children in the study had measles in the past, but all had the MMR" stated David Whalgren.

Vaccines and Demyelination:

  • Herroelen, L et al, "Central-Nervous-System Demyelination After Immunization with Recombinant Hepatitis B Vaccine", Lancet, Nov 9, 1991, 338(8776):1174-1175.
  • Kaplanski G, Retornaz F, Durand J, Soubeyrand J, "Central nervous system demyelination after vaccination against hepatitis B and HLA haplotype." J Neurol Neurosurg Psychiatry 1995 Jun; 58(6):758-759.
  • Matyszak MK, Perry VH, "Demyelination in the central nervous system following a delayed-type hypersensitivity response to bacillus Calmette-Guerin." Neuroscience 1995 Feb;64(4):967-977.
  •  Tornatore CS, Richert JR, "CNS demyelination associated with diploid cell rabies vaccine." Lancet 1990 Jun 2;335(8701):1346-1347.
  • Adams, JM et al, "Neuromyelitis Optica: Severe Demyelination Occurring Years After Primary Smallpox Vaccinations", Rev Roum Neurol, 1973, 10:227-231.
  • In 1988, Dietrich used MRI to show that developmentally delayed children had alterations in their myelin. Coulter described that central nervous system damage can be exhibited as abnormal behavior of the child. In 1935, Thomas Rivers, experimental allergic encephalitis (EAE) can be the result of a viral or bacterial infection of the nervous system. "The fact of the matter is that it is a matter of record that it was known that vaccination produced encephalitis since 1926." The authors stated, "In regions in which there is no organized vaccination of the population, general paralysis is rare. ... It is impossible to deny a connection between vaccinations and the encephalitis (brain damage) which follows it." Vaccines have been linked to seizures, convulsions and epilepsy.

Vaccines and Seizures:

  • Hirtz DG, Nelson KB, Ellenberg J H, "Seizures following childhood immunizations", Pediatr 1983 Jan; 102(1):14-18.
  •  Cherry JD, Holtzman AE, Shields WD, Buch D, Nielsen, "Pertussis immunization and characteristics related to first seizures in infants and children,"J Pediatr 1993 Jun;122(6):900-903.
  •  Coplan J, "Seizures following immunizations," J Pediatr 1983 Sep;103(3):496.
  •  Barkin RM, Jabhour JT, Samuelson J S, "Immunizations, seizures, and subsequent evaluation," JAMA 1987 Jul 10;258(2):201.
  • Griffin MR, et al, "Risk of seizures after measles-mumps-rubella immunization," Pediatrics 1991 Nov;88(5):881-885.
  •  Griffin MR, et al, "Risk of seizures and encephalopathy after immunization with the diphtheria-tetanus-pertussis vaccine," JAMA 1990 Mar 23-30;263(12):1641-1645.
  •  Cizewska S, Huber Z, Sluzewski W, "[Prophylactic inoculations and seizure activity in the EEG]," Neurol Neurochir Pol 1981 Sep-Dec;15(5-6):553-557. [Article in Polish]
  •  Huttenlocher PR, Hapke RJ, "A follow-up study of intractable seizures in childhood." Ann Neurol 1990 Nov; 28(5):699-705.
  • Blumberg DA, "Severe reactions associated with diphtheria-tetanus-pertussis vaccine: detailed study of children with seizures, hypotonic-hypo-responsive episodes, high fevers, and persistent crying."Pediatrics 1993 Jun; 91(6):1158-1165.

Vaccines and Convulsions:

  • Prensky AL, et al, "History of convulsions and use of pertussis vaccine," J Pediatr 1985 Aug; 107(2):244-255.
  • Baraff LJ, "Infants and children with convulsions and hypotonic-hypo-responsive episodes following diphtheria-tetanus-pertussis immunization: follow-up evaluation," Pediatrics 1988 Jun; 81(6):789-794.
  • Jacobson V, "Relationship of pertussis immunization to the onset of epilepsy, febrile convulsions and central nervous system infections: a retrospective epidemiologic study," Tokai J Exp Clin Med 1988;13 Suppl: 137-142.
  • Cupic V,et al, "[Role of DTP vaccine in the convulsive syndromes in children]," Lijec Vjesn 1978 Jun; 100(6):345-348. [Article in Serbo-Croatian (Roman)]
  • Pokrovskaia NIa, "[Convulsive syndrome in DPT vaccination (a clinico-experimental study)]," Pediatriia 1983 May;(5):37-39. [Article in Russian]

Vaccines and Epilepsy:

  • Ballerini, Ricci, B, et al, "On Neurological Complications of Vaccination, With Special Reference to Epileptic Syndromes," Riv Neurol, Jul-Aug 1973, 43:254-258.
  •  Wolf SM, Forsythe A, "Epilepsy and mental retardation following febrile seizures in childhood," Acta Paediatr Scand 1989 Mar;78(2):291-295.

Vaccines and Brain Swelling:

  • Iwasa, S et al, "Swelling of the Brain in Mice Caused by Pertussis ... Quantitative Determination and the Responsibility of the Vaccine", Jpn J Med Sci Biol, 1985 , 38(2):53-65.

  •  Mathur R, Kumari S, "Bulging fontanel following triple vaccine." Indian Pediatr 1981 Jun;18(6):417-418.

  •  Barry W, Lenney W, Hatcher G, "Bulging fontanelles in infants without meningitis." Arch Dis Child 1989 Apr;64(4):635-636.

  •  Shendurnikar N, "Bulging fontanel following DPT" Indian Pediatr 1986 Nov;23(11):960.

  •  Gross TP, Milstien JB, Kuritsky JN, "Bulging fontanelle after immunization with diphtheria-tetanus-pertussis vaccine and diphtheria-tetanus vaccine." J Pediatr 1989 Mar;114(3):423-425.

  •  Jacob J, Mannino F, "Increased intracranial pressure after diphtheria, tetanus, and pertussis immunization." Am J Dis Child 1979 Feb;133(2):217-218.

  • Dugmore, WN, "Bilateral Oedema at the Posterior Pole. Hypersensitivity Reaction to Alavac P injection." Br J Ophthalmol, Dec 1972, 55:848-849.

Vaccines and Neurological Damage

  • Nedar P R, and Warren, R J, "Reported Neurological Disorders Following Live Measles Vaccine", 1968, Ped, 41:997-1001.

  • Paradiso, G et al, "Multifocal Demyelinating Neuropathy after Tetanus Vaccine", Medicina (B Aires), 1990, 50(1):52-54.

  • Landrigan, PJ, Whitte, J, "Neurologic Disorders Following Live Measles-virus Vaccination", JAMA, Mar 26, 1973, v223(13):1459-1462.

  • Turnbull, H M, "Encephalomyelitis Following Vaccination", Brit Jour Exper Path, 7:181, 1926.

  • Kulenkampff, M et al, "Neurological Complications of Pertussis Inoculation", Arch Dis Child, 1974, 49:46.

  • Strom, J, "Further Experience of Reactions, Especially of a Cerebral Nature in Conjunction with Triple Vaccination", Brit Med Jour, 1967, 4:320-323.

  • Berg, J M, "Neurological Complications of Pertussis Immunization," Brit Med Jour, July 5,1958; p 24.

  • Bondarev, VN et al, "The Changes of the Nervous System in Children After Vaccination", Pediatria, Jun 1969; 48:20-24.

  • Badalian, LO, "Vaccinal Lesions of the Nervous System in Children," Vop Okhr Materin Dets, Dec 1959, 13:54-59

  • Lorentz, IT, et al, "Post-Vaccinal Sensory Polyneuropathy with Myoclonus", Proc Aust Ass Neurol, 1969, 6:81-86.

  • Trump, R C, White, T R, "Cerebellar Ataxia Presumed Due To Live Attenuated Measles Virus Vaccine," JAMA, 1967, 199:165-166.

  • Allerdist, H, "Neurological Complications Following Measles Vaccination", Inter Symp, Brussels, 1978, Development Biol Std, Vol 43, 259-264.

  • Finley, K H, "Pathogenesis of Encephalitis Occurring With Vaccination, Variola and Measles, Arch Neur and Psychologist, 1938; 39:1047-1054.

  • Froissart, M et al, "Acute Meningoencephalitis Immediately after an Influenza Vaccination", Lille Med, Oct 1978, 23(8):548-551.

  • Pokrovskaia, Nia, et al, "Neurological Complications in Children From Smallpox Vaccination", Pediatriia, Dec 1978, (12):45-49.

  • Allerdist, H, "Neurological Complications Following Measles Virus Vaccination. Evaluation of the Cases seen Between 1971-1977", Monatsschr Kinderheilkd, Jan 1979, 127(1): 23-28.

  • Ehrengut, W et al, "On Convulsive Reactions Following Oral vaccination Against Polio", Klin Paediatr, May 1979, 191(3):261-270.

  • Naumova, R P, et al, "Encephalitis Developing After Vaccination without a Local Skin Reaction", Vrach Delo, Jul 1979, (7):114-115.

  • Goswamy, BM, "Neurological Complications After Smallpox Vaccination", J Ass Phys India, Jan 1969, 17:41-43.

  • Schchelkunov, SN et al, "The Role of Viruses in the Induction of Allergic Encephalomyelitis," Dokl Akad Nauk SSSR, 1990,315(1):252-255. [Vaccines contain viruses, too]

  •  Walker AM, "Neurologic events following diphtheria-tetanus-pertussis immunization," Pediatrics 1988 Mar;81(3):345-349.

  • Shields WD, et al, "Relationship of pertussis immunization to the onset of neurologic disorders: a retrospective epidemiologic study," J Pediatr 1988 Nov; 113(5):801-805.

  • Wilson J, "Proceedings: Neurological complications of DPT inoculation in infancy," Arch Dis Child 1973 Oct; 48(10):829-830.

  • Iakunin IuA, "[Nervous system complications in children after preventive vaccinations]," Pediatriia 1968 Nov; 47(11):19-26. [Article in Russian]

  • Greco D, et al, "Case-control study on encephalopathy associated with diphtheria-tetanus immunization in Campania, Italy," Bull World Health Organ 1985;63(5):919-925.

  • Ehrengut W at Institute of Vaccinology and Virology, Hamburg, Germany states, "Bias in the evaluation of CNS complications following pertussis immunization are the following: 1) Notifications of post-immunization adverse events, 2) Publications by vaccine producers on the frequency of adverse reactions, 3) Comparison of permanent brain damage after DPT and DT immunization, 4) Pro-immunization, 5) Immunization associated viral encephalitis, 6) Accuracy of statistics, 7) Personal. A review of these points indicates an underestimation of CNS complications after pertussis immunization."

  • Reference: Ehrengut W, "Bias in evaluating CNS complications following pertussis immunization." Acta Paediatr Jpn, 1991 Aug; 33(4):421-427.


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